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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2410 | Nedaplatin | NSC 375101D | DNA/RNA Synthesis |
Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand... | |||
T34628 | SG3199 | SG 3199,SG-3199 | |
SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematologi... | |||
T72817 | Colibactin 742 | ||
Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to G2/M arrest. | |||
T68675 | Porfiromycin | ||
Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic... | |||
T68942 | Caricotamide | ||
Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the pro... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T0974 | Novobiocin Sodium | Albamycinsodium,Cathomycin,Albamycin | Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy |
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim... | |||
T4558 | Trioxsalen | Trimethylpsoralen,Trioxysalen,Trisoralen | DNA Alkylator/Crosslinker , DHFR |
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01270 | TRAIP Protein, Human, Recombinant (His) | Human | E. coli |
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe... | |||
TMPH-00043 | Fanconi-associated nuclease 1 Protein, Ailuropoda melanoleuca, Recombinant (His & Myc) | Ailuropoda melanoleuca | E. coli |
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien... | |||
TMPH-02649 | FAN1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien... | |||
TMPH-01267 | RNF13 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein... |