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Search Results for " DNA interstrand cross-links "

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5

阻害剤

2

天然化合物

4

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T2410 Nedaplatin NSC 375101D DNA/RNA Synthesis
Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand...
T34628 SG3199 SG 3199,SG-3199
SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematologi...
T72817 Colibactin 742
Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads to G2/M arrest.
T68675 Porfiromycin
Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic...
T68942 Caricotamide
Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the pro...
カタログ番号 製品名 別名 ターゲット
T0974 Novobiocin Sodium Albamycinsodium,Cathomycin,Albamycin Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T4558 Trioxsalen Trimethylpsoralen,Trioxysalen,Trisoralen DNA Alkylator/Crosslinker , DHFR
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPH-01270 TRAIP Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
TMPH-00043 Fanconi-associated nuclease 1 Protein, Ailuropoda melanoleuca, Recombinant (His & Myc) Ailuropoda melanoleuca E. coli
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-02649 FAN1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-01267 RNF13 Protein, Human, Recombinant (His & Myc) Human E. coli
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...